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KMID : 0358519930050010029
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Korean Journal of Occupational and Environmental Medicine
1993 Volume.5 No. 1 p.29 ~ p.44
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The Study on the Urinary N-Acetyl-beta-Glucosaminidase Concentrations as an Early Renal Injury Index in Workers Exposed to Lead, Nercury and Orgarnic Solvents
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Abstract
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The urinary N-Acetyl-β-Glucosaminidase activity test has been recommended as sensitive method to detect early renal dysfunction by many toxic chemicals. To catch the high reference value of urinary N-Acetyl-β-Glucosaminidase activity in Korean,
the
total of 108 reference workers exposed only to noise were surveyed. And N-Acetyl-β-Glucosaminidase activities in 42 mercury workers at a fluorescent lamp manufacturing factory and 50 reference workers were measured to detect early renal
dysfunction of
mercury workers. The total of 27 mercury workers were followed 1 year to examine change of the N-Acetyl-β-Glucosaminidase activities according to the change of urinary mercury level. It was also examined to the N-Acetyl-β-Glucosaminidase
activities of
8 lead exposed workers and 44 carbon disulfide exposed workers.
It was examined to the correlation coefficients between the N-Acetyl-β-Glucosaminidase activities and total protein, α-1-microglobulin, β-2-microglobulin in 24 hour urine in 42 carbon disulfide exposed workers and 14 students as refernce
group.
And
the correlation coeffecients between the N-Acetyl-β-Glucosaminidase activities in 24 hour urines and in spot urines were measured in 12 lead exposed workers and 43 mercury exposed workers.
@ES The results were as follows;
@EN 1. The high reference value of urinary N-Acetyl-β-Glucosaminidase activities in Korean was 180 nanomole methylumbellyferon/mg creatine of urine.
2. The correlation coefficients of N-Acetyl-β-Glucosaminidase activities and microalbumin, α-1-microglobulin, β-2-microglobulin in 24 hour urine were about 0.5 respectively.
3. The values of N-Acetyl-β-Glucosaminidase activities of spot urines in mercury exposed workers were statistically significant higher than those in reference group. And about 76.5% of workers of whom the urinary mercury level decreased after 1
year
follow-up, also decreased the values of N-Acetyl-β-Glucosaminidase activities of spot urines.
4. There was no significant correlation between the N-Acetyl-β-Glucosaminidase activity of spot urines blood lead level in lead exposed workers. But a half of workers have increased N-Acetyl-β-Glucosaminidase activities above the reference
level.
5. The values of N-Acetyl-β-Glucosaminidase activities of spot urines in carbon disulfide exposed workers were statistically significantly higher than those in reference group. And for workers exposed to carbon disulfide and having retinopathy,
the
mean values of the N-Acetyl-β-Glucosaminidase activities were significantly higher, as compared to those having normal retina.
6. The correlation coefficients of N-Acetyl-β-Glucosaminidase activities between the values of 24 hour urines and those of spot urine were 0.76 in carbon disulfide exposed workers, 0.5 in lead exposed workers, 0.4 in mercury exposed workers,
respectively. Among the correlation coefficients between the values of 24 hour urine and those of spot urines, the correlation coefficients between the values of first morning urine samples and those of 24 hour urine samples were highest.
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KEYWORD
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